Theoretical and Simulation Study of Lipid Membranes Application to Lipid Rafts

Proper functioning of biological membranes is in§large part due to cholesterol's ability to regulate§fluidity of a lipid bilayer. The evidence suggests§that cholesterol participates in the formation of§cholesterol- and sphingolipid-enriched domains known§as rafts in the plasma and other membranes of§animal cells. Rafts have been identified as an§important membrane structural units in signal§transduction, protein transport and sorting of§membrane components. The goal of this research is to§model raft-like membrane domains with tools of§computational biophysics. In the first part of the§work, mixtures of sphingomyelin lipid and cholesterol§are investigated using molecular dynamics and§Monte-Carlo simulations. In the second part of the§book, a novel dynamic mean-field model is developed§to investigate phase properties of lipid-cholesterol§membranes. This new technique allows studying large§bilayer patches on microsecond timescales, and has§powerful predictive capability. The material in this§book is most suitable for computational biophysicists§and biologists, as well as for scientists working in§statistical and condensed matter physics fields.