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This book will present original results as well opinionated overviews of the current state of knowledge of the problem of anesthesia-induced unconsciousness and amnesia. It will present evidence from molecular to system levels and lead to an integrative theory of anesthetic-induced unconsciousness and amnesia. The hypothesized mechanism underlying anesthetic action will be explored as a demonstration of "bridging the gap" between bench and clinical research. It will synthesize information spanning a number of levels from molecular integrative that has begun to reveal answers to the longstanding mystery of anesthesia.