Mitochondrial Intoxication

Mitochondrial Intoxication, Second Edition offers a comprehensive and fully updated exploration of the impact of toxic molecules on mitochondrial physiology, and the diseases that result from their dysfunction. Divided into three sections, the book opens with a detailed overview of mitochondrial physiology, molecular markers of mitochondrial intoxication and challenges of mitochondrial profiling during pre-clinical studies. It then focuses on endogenous toxicants and their impact on mitochondria, including new chapters on lipids, glucose and microbiota-derived toxicants. Amyloid-β peptide and its impact on mitochondrial dysfunction is also a new addition to this book, as well as inflammation-induced mitochondrial intoxication. The final section explores exogenous toxicants, such as pollutants, food additives, illicit and pharmaceutical drugs, pesticides and heavy metals. The effects of micro- and nanoplastics on mitochondrial function are newly covered. Furthermore, the latest computational tools in mitochondrial toxicity research are investigated. Incorporating the latest advances in the field, “Mitochondrial Intoxication, Second Edition” offers cutting-edge insights on mitochondrial toxicity, and serves as an invaluable resource for researchers and advanced students in cell biology, molecular biology, toxicology, biochemistry, pharmacology, and related fields.

• Covers molecular markers of mitochondrial intoxication
• Includes case studies that illustrate the health impacts of toxicity upon mitochondria
• Provides new insights on environmental contaminants like microbiota-derived molecules and micro- and nanoplastics and their impact on mitochondrial physiology
• Investigates endogenous molecules such as cholesterol, glucose, and beta-amyloid peptides affecting mitochondrial health
• Explores computational tools and their application to mitochondrial toxicity research