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The discovery of Lyme disease, biologically better termed Lyme borreliosis, has provided scientists with a tremendous opportunity to elucidate pathophysiologic mechanisms in borrelial infections. Large, carefully designed, and mostly prospective clinico-epidemiologic studies are the basis for the evidence-based review chapters that constitute Lyme Borreliosos: Epidemiology and Clinical Applications. Clinicians will find herein a body of knowledge that will facilitate their management of patients, as well as arm them with authoritative information they can use to dispel the myths about tick-borne infections that have crept into the popular knowledge.