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Annette Barchanski deals with the question how§to design nanoparticles for biomedical research. She considers properties such§as size, charge, biocompatibility, and functionalization of nanoparticles from§a biologist's point of view in order to achieve specific cellular responses.§The author discusses the structure-function relationship of nanoparticle§conjugates derived from a laser-based fabrication method. Both the limits and§perspectives of tunable conjugate functions are presented, providing a general§outline for researchers to configure functionalized nanoparticles with a§specifically optimized design for biomedical requests, e.g. in biomedical§engineering regenerative science and reproductive biology.§