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This book describes in depth the design, research, and future of brain research from the context of implantable micro- and nano- systems and technologies. It should enable readers to create neural integrated microsystems that satisfy the needs for complex neuroscientific cognitive studies, brain-machine interface studies, as well as neuro-prosthetic devices to improve healthcare. The author takes a multi-disciplinary approach and coverage includes topics from electrical, biomedical or mechanical engineering, relating specifically to implantable microsystems.