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Anaerobiosis and Stemness: An Evolutionary Paradigm for Therapeutic Applications provides a context for understanding the many complexities and evolutionary features of stem cells. This work provides a new perspective that brings together researchers of different backgrounds to advance the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation. * Highlights the molecular and evolutionary features of stem cells which make them so important to all biological research* Explores methods of isolation, characterization, activation, and maintenance of stem cells* Includes models for clinical application in regenerative medicine, cancer therapy, and transplantation