Advances in Immunology

'The series which all immunologists need' - "The Pharmaceutical Journal". '"Advances in Immunology" must find itself among the most active volumes in the libraries of our universities and institutions' - "Science". 'Deserves a permanent place in biomedical libraries as an aid in research and in teaching' - "Journal of Immunological Methods". 'A provocative and scholarly review of research' - "Journal of the American Medical Association". 'Provides an extremely valuable source of reference and many stimulating ideas...the main repository of information in a rapidly devloping subject' - "The Lancet". 'Provides unrivalled value in both academic and fiscal terms and should be purchased by hard pressed librarians as a major priority to be jealously defended' - "Journal of Medical Microbiology". 'A very valuable serial publication...no serious student of immunology can afford to be without it' - "Archives of Biochemistry and Biophysics". Key features of this title are as mentioned below. It focuses on: components of the V(D)J recombination machinery that might be related to diseases in humans and animals; control of the complement system by control of C3/C5 convertase on host cells, control of fluid phase C3/C5 convertases, control of fluid phase MAC, and control of deposited MAC; immunodeficiency resulting from a complete absence of MHC class II expression and two trans-acting factors controlling transcription; current knowledge of IL-2R signaling, highlighting IL-2 signaling, and T-cell growth regulation; and, functional role of CD40 in cells, the in vivo significance of CD40-CD40-L interactions, and the signal transduction machinery activated following crosslinking of the CD40 antigen. It presents an integrative approach to better understand the observed heterogeneity of an individual response to allergens. It also focuses on regulation of isotype specificity, switch recombination regulation, and the mechanism of switching, and two lymphocyte-specific proteins, RAG1 and RAG2, initiate V(D)J recombination of antigen receptor genes.