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Statistical Methods for CGH Array Analysis

Name: Statistical Methods for CGH Array Analysis
Brand: VDM Verlag
SKU: 06820282
Price: 17783 HUF
Availability: InStock
Author: Pei Wang
ISBN: 9783639114065

Pei Wang

Language

English

Book Paperback

Libristo code: 06820282

Publishers VDM Verlag, February 2010

Genomic DNA copy number alterations are key genetic events in the initiation and progression of huma... Full description

Libristo code: 06820282

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Genomic DNA copy number alterations are key genetic events in the initiation and progression of human cancers. Recent advance in the technique of microarray comparative genomic hybridization (array CGH) enables one to screen genome-wide for all possible regions with DNA copy number alterations, such as chromosome gains and losses, or localized amplifications and deletions. In this book, we introduce two statistical methods addressing two different questions for the data analysis of array CGH. The first method---Cluster Along Chromosomes--- is developed for calling gains and losses in CGH arrays. The second method--- Boosted PRIM (Patient Rule Induction Method)--- is developed to search for oncogenic pathways using array-CGH data. The performance of the methods are illustrated through both simulation studies and real applications.

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About the book

Full name Statistical Methods for CGH Array Analysis

Author Pei Wang

Language

English

Binding Book - Paperback

Date of issue 2010

Number of pages 38

EAN 9783639114065

ISBN 363911406X

Libristo code 06820282

Publishers VDM Verlag

Weight 68

Dimensions 152 x 229 x 2

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