PRF in Endodontics

This book focuses on Platelet-rich fibrin (PRF) which belongs to a new generation of platelet concentrates, geared to simplified preparation without biochemical blood handling. Platelet-rich fibrin (PRF) is a surgical biologic additive that is prepared by manipulation of autologous blood. It has now evolved to become one of the most widely used platelet concentrates in dentistry. It has almost replaced Platelet-rich plasma (PRP) for usage owing to its advantages such as being 100% autogenous, easy technique, time and cost-effective, superior & prolonged growth factor release. Research conducted in recent years showed the potential of blood concentrates as a scaffold in the process of tissue regeneration. PRF is a natural product; therefore, it is biodegradable and biocompatible. For this reason, there is no unneeded waste while obtaining it. Due to its biocompatibility, it does not cause allergic reactions. PRF has gained tremendous attention in recent years because of its capacity to successfully regenerate both soft and hard tissues, enhancing new blood vessels (angiogenesis) and tissue formation during healing.