Free shipping on orders over 19,990 Ft via Packeta, Fox Post Box, and DPD Collection Point

Check order status

Become part of a community of book lovers from all over the world and get access to a whole bunch of benefits. Create an account for free

Free delivery for purchases over 19 990 Ft

DPD point 990 Ft DPD courier 1 190 Ft GLS point 1 190 Ft Hungarian Post 1 795 Ft Hungarian Post 1 690 Ft Hungarian Post 1 690 Ft FoxPost 1 190 Ft Packeta point 1 190 Ft GLS courier 1 690 Ft

Contact

How to shop

Help

My account

▸ Empty :-(

Free shipping on orders over 19,990 Ft via Packeta, Fox Post Box, and DPD Collection Point

Polyglutamine Disorders

Clévio Nóbrega

Luís Pereira de Almeida

Language

English

Book Paperback

Libristo code: 21298678

Publishers Springer International Publishing AG, June 2019

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two mai... Full description

Libristo code: 21298678

324 b

48 445 Ft

In stock at our supplier Shipping in 5-8 days

Up to 30 days for returns

Customers also purchased

Trois siècles d'opéra à Lyon CORNELOUP

Paperback

4 564 Ft

Kiel - Die Förde! (Wandkalender 2026 DIN A4 quer), CALVENDO Monatskalender Calvendo

Calendar

7 093 Ft

Les Séquences Cultes des Classiques Disney Renaut

Paperback

8 098 Ft

Glukózová revolúcia Jessie Inchauspé

Paperback

6 239 Ft

Our Days Swaraj Bhatia

Paperback

10 520 Ft

Język polski ćwiczenia dla klasy 5 między nami wersja b wydanie rozszerzone szkoła podstawowa wyd.2021 Agnieszka Łuczak|Anna Murdzek

Paperback

1 737 Ft

SUEÑOS ÁRTICOS BARRY LOPEZ

Paperback

8 726 Ft

Schein-Heilig Die Hafenprinzessin

Paperback

3 308 Ft

Français 2 ESO: Cahier d'activités. Promenade

Paperback

8 948 Ft

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies' development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington's disease (HD); spinal-bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.