Contact
How to shop
Delivery
Shopping guide
Muscular Dystrophy Duchenne Modifying Genes and Pathways
English
188 b
Up to 30 days for returns
Customers also purchased
/
Paperback
22 988
Ft
/
Paperback
6 335
Ft
/
Paperback
7 870
Ft
/
Adobe ePub DRM
5 152
Ft
/
Hardback
1 098
Ft
/
Paperback
27 221
Ft
DMD is the most common muscular dystrophy in childhood and incurable to date. It is caused by the absence of dystrophin, what influences several signal transduction pathways. The thesis is interested in the investigation and modulation of signal transduction pathways that may compensate the lack of dystrophin as an alternative therapy strategy. To study dystrophin downstream pathways, the mRNA expression of DMD patients and two DMD siblings with an intra-familially different course of DMD were analysed. Genes, found differently expressed in the two DMD siblings, are first part of a signalling pathway linking dystrophin, which is first represented in a Petri net. The central point of this pathway is the transcription factor NFATc. Invariant and theoretical knockout analyses of the net were applied. On human SkMCs, modulation of protein activity and of gene expression using siRNA, vector-DNA, and chemical substances were performed. The cells were studied by proliferation and vitality tests as well as expression analyses at mRNA and protein level. According to the basic idea of this study, a new therapeutic strategy becomes apparent, which considers dystrophin downstream processes.
About the book
English
Give this book today
It's easy
1 Add to cart and choose Deliver as present at the checkout 2 We'll send you a voucher 3 The book will arrive at the recipient's addressYou might also be interested in
/
Hardback
124 099
Ft
/
Paperback
5 242
Ft
/
Paperback
12 013
Ft
/
Paperback
14 233
Ft
/
Paperback
12 747
Ft
/
Paperback
5 478
Ft
/
Paperback
8 319
Ft
Hi! I'm Libroamiko, your book advisor.
How can I help you?