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Modelling Proteasome Dynamics in a Bayesian Framework

Name: Modelling Proteasome Dynamics in a Bayesian Framework
Brand: Springer Fachmedien Wiesbaden
SKU: 18368854
Price: 21201 HUF
Availability: InStock
Author: Sabine Stübler
ISBN: 9783658201661

Sabine Stübler

Language

English

Book Paperback

Libristo code: 18368854

Publishers Springer Fachmedien Wiesbaden, December 2017

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and a... Full description

Libristo code: 18368854

145 b

21 201 Ft

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Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor's transport parameters for strong or isoform-specific inhibition.

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About the book

Full name Modelling Proteasome Dynamics in a Bayesian Framework

Author Sabine Stübler

Language

English

Binding Book - Paperback

Date of issue 2017

Number of pages 96

EAN 9783658201661

ISBN 3658201665

Libristo code 18368854

Publishers Springer Fachmedien Wiesbaden

Weight 1557

Dimensions 148 x 210 x 6

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