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Modelling Atherosclerosis

Name: Modelling Atherosclerosis
Brand: Omniscriptum
SKU: 06985140
Price: 13544 HUF
Availability: InStock
Author: Nader el Khatib
ISBN: 9786131527982

Towards the Mathematical Prediction

Nader el Khatib

Language

English

Book Paperback

Libristo code: 06985140

Publishers Omniscriptum, February 2018

Atherosclerosis is an inflammatory disease which starts when low density lipoproteins (LDL) enter th... Full description

Libristo code: 06985140

92 b

13 544 Ft

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Atherosclerosis is an inflammatory disease which starts when low density lipoproteins (LDL) enter the intima of blood vessel where they are oxidized (ox-LDL). The ox-LDL is considered as a dangerous agent by the immune system provoking an anti-inflammatory response. This immune response triggers the recruitment of monocytes into the intima where they differentiate into macrophages and foam cells. The latter amplifies the production of inflammatory cytokines and further recruitment of monocytes. This auto-amplified process is compensated by the secretion of anti-inflammatory cytokines biochemical anti-inflammation) and triggers the migration of smooth muscle cells to form a fibrous cap that covers the lipid core. These fibrous caps with the lipid core are called atherosclerosis plaque. It changes the geometry of the blood vessel by narrowing it and interacts with the blood flow. This interaction may have dangerous consequences related to the plaque rupture or to the formation of blood clot. This book is devoted to mathematical modelling ofthese phenomena.