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Mitochondrial Oxidative Phosphorylation

Name: Mitochondrial Oxidative Phosphorylation
Brand: Springer-Verlag New York Inc.
SKU: 01427802
Price: 78925 HUF
Availability: InStock
Author: Bernhard Kadenbach
ISBN: 9781461435723

Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology

Bernhard Kadenbach

Language

English

Book Hardback

Libristo code: 01427802

Publishers Springer-Verlag New York Inc., June 2012

This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxid... Full description

Libristo code: 01427802

541 b

78 925 Ft

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This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.