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Mitochondrial Alterations in Solid Carcinomas

Name: Mitochondrial Alterations in Solid Carcinomas
Brand: VDM Verlag Dr. Mueller E.K.
SKU: 07008180
Price: 17548 HUF
Availability: InStock
Author: David Meierhofer
ISBN: 9783836486408

Relationship between Tumorgenesis of Human Kidney Carcinomas and Mitochondrial DNA (mtDNA) Alterations

David Meierhofer

Language

English

Book Paperback

Libristo code: 07008180

Publishers VDM Verlag Dr. Mueller E.K., March 2008

Alterations of the respiratory chain and mutations of the mitochondrial DNA (mtDNA) have been extens... Full description

Libristo code: 07008180

121 b

17 548 Ft

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Alterations of the respiratory chain and mutations of the mitochondrial DNA (mtDNA) have been extensively investigated in a wide variety of neoplasias. However, no obvious correlation of a certain type of tumor and mtDNA mutations has been reported so far. I compared both, enzymatic measurements of the respiratory chain and mtDNA mutations in renal carcinomas and renal oncocytomas. To enable a high throughput screen of mtDNA variations, I developed a DHPLC-based protocol for a rapid detection of unknown variations of the entire human mtDNA. The benign renal oncocytomas were in clear contrast to the malign renal carcinomas. The oncocytomas showed significantly increased Krebs cycle- and OXPHOS enzyme activities, except a total breakdown of the complex I enzyme activity. The mutation screening revealed frame shift mutations, encoding mitochondrial ND genes in 8 out of 12 oncocytomas. All these somatic frame shift mutations displayed a homoplasmy of 100%. This study shows for the first time a direct correlation of mtDNA mutations in a specific type of cancer, which leads to a total lack of complex I enzyme activity in the respiratory chain.