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Leukotrienes

Name: Leukotrienes
Brand: Springer
SKU: 01397786
Price: 63719 HUF
Availability: InStock
Author: Ian Rodger
ISBN: 9780792387381

New Concepts and Targets for Therapy

Ian Rodger

Jack H. Botting

Sven-Erik Dahlén

Language

English

Book Hardback

Libristo code: 01397786

Publishers Springer, February 1998

In the two decades since the elusive "slow reacting substance of anaphylaxis" (SRS-A) was identified... Full description

Libristo code: 01397786

437 b

63 719 Ft

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In the two decades since the elusive "slow reacting substance of anaphylaxis" (SRS-A) was identified as a product of the action of the 5-lipoxygenase enzyme on arachidonic acid, it has been well established that the leukotrienes are key mediators of both alIergy and inflammation. Their release by alIergen or other challenge has been demonstrated in the lungs of asthmatic subjects, and measurement of urinary leukotriene concentrations in such patients has been shown to be a valuable, non invasive indicator. Significant progress has been made towards the characterization of the leukotriene receptor subtypes, exemplified by the cloning of the LTB4 receptor earlier this year. Coupled with this there has been a continued elucidation of signal transduction mechanisms underlying receptor activation. Consequent upon these advances has been the development of potent antagonists of the CysLT receptor, J and both these and inhibitors of leukotriene biosynthesis have entered clinical practice in the therapy of asthma. In this clinical setting antagonists of the CysLTJ receptor have been shown to be an effective therapy in chronic asthmatics, against antigen- and exercise-induced bronchoconstriction, and in aspirin-intolerant asthmatics. The advent of this new class of agents promises to change the way in which asthmatic patients are currently treated.