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Leucocyte Trafficking

Role of Fucosyltransferases and Selectins

Language EnglishEnglish
Book Hardback
Book Leucocyte Trafficking A. Hamann
Libristo code: 01562612
An essential component of inflammation is the migration of circulating leukocytes from blood into ti... Full description
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An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactionsof selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.

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About the book

Full name Leucocyte Trafficking
Language English
Binding Book - Hardback
Date of issue 2003
Number of pages 242
EAN 9783540401124
ISBN 3540401121
Libristo code 01562612
Weight 1210
Dimensions 140 x 216 x 18
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