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Les Maladies Prions

Language FrenchFrench
Book Paperback
Book Les Maladies   Prions Valérie Defaweux
Libristo code: 06918146
Publishers Omniscriptum, February 2018
Le tropisme cellulaire des prions infectieux diffčre selon l'espčce animale, celui-ci est corrélé ŕ... Full description
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Le tropisme cellulaire des prions infectieux diffčre selon l'espčce animale, celui-ci est corrélé ŕ la souche infectieuse et ŕ des facteurs spécifiques de l'hôte. Par exemple, certains prions infectieux sont lymphotropiques, notamment en cas de scrapie chez les moutons et de variant de la maladie de Creutzfeldt-Jakob (vMCJ) chez l'homme. Par opposition, certains prions se caractérisent par un neurotropisme comme observé chez des patients Creutzfeldt-Jakob atteints de la forme sporadique ou chez des bovins atteints d'encéphalopathies spongiformes bovines (ESB). L'hypothčse de notre travail repose sur les observations suivantes : dans le cas du vMCJ et des ESB, l'agent responsable est identique, la voie d'inoculation et les lésions neurologiques le sont également, seul le tropisme de cette souche pour les organes lymphoďdes diffčre. Notre hypothčse de travail est que des propriétés de l'hôte interviennent dans le tropisme de l'agent infectieux. Deux axes de recherche ont été envisagés : La distribution des fibres nerveuses au sein de tissus lymphoďdes associés aux muqueuses et l'expression de PrPc au sein des tissus lymphoďdes et nerveux des espčces bovine et humaine.

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About the book

Full name Les Maladies Prions
Language French
Binding Book - Paperback
Date of issue 2018
Number of pages 224
EAN 9786131500688
ISBN 6131500681
Libristo code 06918146
Publishers Omniscriptum
Weight 336
Dimensions 152 x 229 x 13
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