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G Protein Methods and Protocols

Role of G Proteins in Psychiatric and Neurological Disorders

Language EnglishEnglish
Book Paperback
Book G Protein Methods and Protocols Ram K. Mishra
Libristo code: 02717126
Publishers Humana Press Inc., August 2013
The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotid... Full description
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The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G,, G,, G,, and G12.

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About the book

Full name G Protein Methods and Protocols
Language English
Binding Book - Paperback
Date of issue 2013
Number of pages 433
EAN 9781489942906
ISBN 1489942904
Libristo code 02717126
Publishers Humana Press Inc.
Weight 652
Dimensions 152 x 229 x 25
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