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Drug-Drug Interactions

Name: Drug-Drug Interactions
Brand: Mdpi AG
SKU: 37199403
Price: 20496 HUF
Availability: InStock
Author: Dong Hyun Kim
ISBN: 9783036520353

Dong Hyun Kim

Sangkyu Lee

Language

English

Book Hardback

Libristo code: 37199403

Publishers Mdpi AG, September 2021

Drug-drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy o... Full description

Libristo code: 37199403

138 b

20 496 Ft

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Drug-drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy or increased toxicity of the affected drug. Some well-known interactions are known to be the cause of adverse drug reactions (ADRs) that are life threatening to the patient. Traditionally, DDI have been evaluated around the selective action of drugs on specific CYP enzymes. The interaction of drugs with CYP remains very important in drug interactions but, recently, other important mechanisms have also been studied as contributing to drug interaction including transport- or UDP-glucuronyltransferase as a Phase II reaction-mediated DDI. In addition, novel mechanisms of regulating DDIs can also be suggested. In the case of the substance targeted for interaction, not only the DDIs but also the herb-drug or food-drug interactions have been reported to be clinically relevant in terms of adverse side effects. Reporting examples of drug interactions on a marketed drug or studies on new mechanisms will be very helpful for preventing the side effects of the patient taking these drugs. This Special Issue aims to highlight current progress in understanding both the clinical and nonclinical interactions of commercial drugs and the elucidation of the mechanisms of drug interactions.