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Cardiovascular Specific Gene Expression

Language EnglishEnglish
Book Paperback
Book Cardiovascular Specific Gene Expression P.A.F.M. Doevendans
Libristo code: 01973937
Publishers Springer Netherlands, October 2010
The development of the heart and vessels during embryogenesis depends on the complex interplay of va... Full description
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The development of the heart and vessels during embryogenesis depends on the complex interplay of various cell types and growth factors. The implementation of molecular tools has enabled us to analyze early steps in cardiogenesis and vasculogenesis. Furthermore the introduction of transgenic and knock-out techniques in mice, and the miniaturization of physiologic measurements to the mouse level has fundamentally changed our knowledge. Pathophysiology can be unraveled at the molecular level. The implications of various stimuli on specific membrane receptors can be analyzed. In response to receptor activation, interacting intracellular signaling pathways can activate or block transcription factors. The changes in gene expression lead to functional changes observed in the cardiovascular systems of animal models and humans. Changes in the level of gene expression and protein function in cardiovascular disease are discussed for the sarcomeric, calcium handling and ion channel genes. Furthermore, different approaches to the design of cell-type-specific gene therapy approaches for the heart and vessels are outlined.

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About the book

Full name Cardiovascular Specific Gene Expression
Language English
Binding Book - Paperback
Date of issue 2010
Number of pages 330
EAN 9789048151899
ISBN 9048151899
Libristo code 01973937
Weight 534
Dimensions 160 x 240 x 18
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